How Does Liver Fibrosis Occur
BlogLiver fibrosis is the excessive scarring of liver tissue , which is due to reformist liver inflammation and liver cell death in chronic liver diseases . Liver fibrosis takes place when liver tries to repair its damaged cadre through dethronement of new collagen fibers . This deposit of repaired tissue results in scarred tissue or fibrous tissue paper establishment . This enlarged wound healing reaction interfere with normal liver affair .
Liver fibrosis pass off due to repeated damage cause either by various drugs or by upset . The hepatocytes / the functional liver cells are injured due to trauma , surplus inebriant use of goods and services , toxins , or virus such as hepatitis B or hepatitis C , bilious impedimenta , autoimmune hepatitis , non - alcohol-dependent fatty liver disease ( NAFL ) , and alcohol-dependent liver disease ( ALD ) . However , very seldom is liver fibrosis the primary problem , mostly it is petty to some other liver disease such as liver cirrhosis . The citizenry who are at endangerment of developing liver fibrosis are people above the historic period of 50 years , immunocompromised patient , fatty liver(steatosis ) , resistance to insulin and who are infected with hepatitis B or C virus . Fibrosis is also believed to occur more rapidly in men than char .
Hepatitis C computer virus is know to result in 60 - 70 % of shell and almost 75 % of the case of acute hepatitis reverse into chronic hepatitis . Hepatitis B mostly hap as a co - contagion with hepatitis D and contributes to 5 - 10 % of the casing . A 90 % of the newborn agony with penetrating hepatitis progress to chronic hepatitis and 25 - 50 % also get on to continuing type in young nipper .
Fatty liver mostly occur in multitude who are weighty , diabetic with abnormal tier of cholesterol and fats in the blood . These term will lead to deduction of more fat and ultimately accumulation inside the liver cells cause butterball liver . This fatty liver cause chronic fervour and liver cirrhosis .
alcohol-dependent hepatitis occurs in people who have been drinking heavily for many geezerhood . This leads to widespread inflammation and destruction of liver cells .
drug leading to continuing hepatitis are isoniazid , methyldopa , and nitrofurantoin when they are taken for a long period of prison term .
Other drive of chronic hepatitis include alpha-1 antitrypsin want ( a hereditary upset , celiac diseaseand hemochromatosis . They all in turn lead to liver fibrosis and if not treat liver cirrhosis .
The stages determine the point of price afflicted to the liver . The activity or the foretelling of how the fibrosis is progressing is done based on a pop marking system called the METAVIR scoring system . The activity level tramp from A0 to A3 with A0 give birth no body process , A1 showing mild activity , A2 evidence restrained activity and A3 showing severe activity .
Generally liver fibrosis is not diagnosed in mild to restrained microscope stage , as the symptom do not normally occur until stark liver damage has occurred . The symptoms includeloss of appetite , fatigue duty , lethargy , acerbity , nausea , vomiting , weight loss , collection of fluid in the legs and stomach , genial confusion , excessive sleepiness and comatoseness . Mostly the symptoms are those of liver cirrhosis of the liver . The wit function deteriorates due to unfitness of the damage liver cells to strain toxic substances from the blood , which in turn build up in the blood and gain the psyche .
Diagnosis is made free-base on physical examination , symptoms , line test , liver routine trial ( measuring horizontal surface of liver enzymes and find the liver mapping and bearing of impairment to the liver ) . Other test used areultrasoundelastography , CT scan , charismatic resonance elastography and liver biopsy .
discourse aims at cure the rudimentary cause and palliative treatment such as abstinence from alcohol in cases of alcohol misuse , weightiness reduction in case of fatty liver and anti - viral drug and interferon therapy in cases of hepatitis B and hepatitis C.